There are a lot of supplements out there, and it can be difficult to tell which ones work and which ones are hype. The following list of the top 50 supplements of all time is comprehensive, listing supplements known to work as described. You'll find everything from antioxidants to fat burners, metabolism boosters to joint health supplements here.

1. Acai berry boosts your immune system while flushing toxins and fat cells from the body.

2. Alpha Lipoic Acid increases antioxidants and boosts immunity.

3. Amino acids help metabolize proteins into muscle.

4. Arginine improves heart health.

5. BCAA's help build muscle and boost energy.

6. Beta Carotene improves eye health and immune systems.
   
7. Biotin helps lower cholesterol, and is found in the B complex vitamins.

8. Bitter orange increases metabolism and burns calories faster.

9. Black Cohosh assists in easing the symptoms of menopause.

10. Calcium improves bone and joint health.

11. Carnitine decreases body fat.

12. Cats Claw is used in the treatment and prevention of many illnesses, including digestive problems and arthritis.

13. Chitosan blocks fat from foods from staying in the body.

14. Chondroitin promotes joint health by helping cartilage retain water.

15. Chromium boosts metabolism, decreases appetite and builds muscle.

16. Conjugated linoleic acid reduces body fat and builds muscle.

17. Cranberry aids in urinary tract health and kidney function.

18. Creatine boosts muscle gain and energy levels.

19. Elderberry boosts the immune system.

20. Ephedra boosts metabolism and energy levels and burns fat quickly.

21. Feverfew fights migraine headaches and decreases their frequency.

22. Fish Oil decreases bad cholesterol and decreases chance of heart failure. It also helps fight depression.

23. Folic Acid helps decrease the risk of birth defects.

24. Ginko Biloba improves memory and overall health.

25. Ginseng increases testosterone levels and decreases prolactin levels, which can cause impotence.

26. Glucosamine improves joint health and decreases loss of cartilage in arthritic patients.

27. Goji berries are high in antioxidants and help reverse the aging process.

28. Green Tea boosts metabolism and your immune system.

29. Guar Gum blocks absorption of dietary fat and increases feeling of fullness after eating.

30. Guggulsterones increase metabolism and thyroid function.

31. HMB supplements prevent muscle deterioration and help maintain muscle.

32. Hoodia is a natural appetite suppressant.

33. Hyaluronic Acid removes toxic substances from the cells of the body.

34. Inositol acts as a natural mood stabilizer and antidepressant.

35. Iron supplements help prevent deficiencies that cause anemia.

36. Lecithin breaks down fats at the cellular level.

37. Lycopene is a natural antioxidant.

38. Melatonin is a natural sleep aid.

39. MSM improves joint health.

40. Niacin assists in detoxification of the body, as well as lowering cholesterol.

41. Probiotics are essentially good bacteria that promote general wellness.

42. Protein supplements aid in building and maintaining muscle.

43. Psyllium is a great source of natural dietary fiber.

44. Resveratrol is a popular supplement for anti-aging.

45. Retinol is a natural skin care supplement that decreases acne.

46. Selenium is a natural antioxidant, which boosts your immune system and cleans toxins from the body.

47. White Willow Bark reduces fevers and inflammation, much like aspirin.

48. Vitamin B12 increases nervous system function.

49. Vitamin D helps prevent colon cancer by clearing the body of lithocholic acids.

50. Zinc Gluconate helps fight and prevent acne.